Combinatorial organoid mutagenesis screen reveals gene constellations driving malignant transformation, pathology and chemosensitivity in high-grade serous ovarian carcinoma
Daryl J. Phuong, Coulter Q. Ralston, Tamer Ezzat, Christopher S. Ashe, Amanda P. Armstrong, Andrea Flesken‐Nikitin, Robert J. Yamulla, Alexander Yu. Nikitin, John C. Schimenti
This study uses combinatorial CRISPR mutagenesis in organoids to identify gene combinations driving malignant transformation, pathology, and chemosensitivity in high-grade serous ovarian carcinoma.
bioRxiv · Mar 10, 2025 · PreprintCancer Biology