The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes
Roni Odai, Michèle Leemann, Tamim Al-Murad, Minhal Abdullah, Lena Shyrokova, Tanel Tenson, Vasili Hauryliuk, Janani Durairaj, Joana Pereira, Gemma Catherine Atkinson
The paper predicts structures for 27,000 viral proteins using AlphaFold2, revealing conserved folds across viruses infecting bacteria, archaea, and eukaryotes and identifying a new antiviral toxin-antitoxin system.
Science Advances · Oct 1, 2025Peer-reviewedMolecular Biology