Vasili Hauryliuk

The paper isolates and characterizes six new E. coli-infecting phages from Kazakhstan, expanding a phage collection and demonstrating phage research in high school education.

This study identifies a novel bacterial defense mechanism where nucleoid-associated proteins detect phage-induced genome damage by relocating to the cytoplasm and activating immune effectors.

This study presents cryo-EM structures of UG10 enzymes and elucidates their enzymatic mechanism involving RT and primase domains, showing their anti-phage activity.

The paper isolates and characterizes five Escherichia coli phages, identifies their defense system sensitivities, and highlights the educational value of phage isolation training.

The paper predicts structures for 27,000 viral proteins using AlphaFold2, revealing conserved folds across viruses infecting bacteria, archaea, and eukaryotes and identifying a new antiviral toxin-antitoxin system.

This study identifies nanobodies that modulate Rel and RelA enzyme activity by trapping them in specific conformational states, inhibiting (p)ppGpp synthesis and affecting bacterial virulence.

The paper analyzes 16 nuclease-NTPase systems to identify shared features controlling bacterial anti-phage defense, revealing universal protein complex formation and broad nucleic acid degradation capabilities.

This study identifies 39 compounds active against non-growing uropathogenic E. coli and some against intracellular Shigella flexneri, with several showing selective activity against non-growing bacteria.

The paper shows FaRel2, a toxSAS, specifically targets tRNAGly and tRNAThr by recognizing the acceptor stem, with structural differences explaining specificity variations among toxSASs.

The paper introduces iLund4u, an algorithm to systematically annotate hyper-variability hotspots in phage genomes and plasmids, identifying 13.7K hotspots and 171K diverse protein families across 873K phage and 696K plasmid sequences.

This study identifies the roles of ABCF ATPases YfmR and YkpA/YbiT in resolving ribosomal stalling during protein synthesis in Bacillus subtilis.

This study identifies and characterizes two Escherichia coli TAC systems that mediate antiphage defense by recognizing phage proteins and modifying mRNA to inhibit translation.

This study identifies YlmH as a novel RQC factor in B. subtilis, showing it can replace RqcP in polyalanine tail addition and is conserved in bacteria lacking RqcP.

The paper shows that viral proteins activate PARIS-mediated tRNA degradation, and viral tRNAs rescue infection by preventing cleavage.

The paper shows that CspA promotes ribosome progression during translation of cold-induced mRNA structures, enhancing translation at low temperatures.

This study investigates the auto-regulation of E. coli RelA through intramolecular interactions, finding that dimerization is not the key regulatory mechanism.

This study reveals a guanosine-switch mechanism that regulates the opposing activities of bifunctional Rel enzymes through allosteric changes.

The paper analyzes ABCF ATPases across 4505 genomes to uncover their diversity, subfamily relationships, and roles in antibiotic resistance and ribosome function.