Degree-ranked gene lists omit the cross-module connectors, and a partition-free centrality recovers them
Qun Zhao, Huaizheng Zheng, Yuxin Zhang, Jieying Bi, Tan Sun
The paper shows that standard gene centrality measures miss cross-module connectors and introduces EDVS, a partition-free centrality measure that recovers these genes without functional annotations.
bioRxiv · Aug 21, 2026 · PreprintBioinformatics