Li Chen

A Cell-Autonomous Cold Sensor Promotes Lipolysis Through Phase Separation

The paper identifies a cell-intrinsic cold-sensing mechanism that enhances lipolysis through phase separation of perilipin 1 in adipose tissue.

SWELL1 channel-mediated D-2HG export promotes immune evasion and metabolic fitness in IDH-mutant gliomas

This study identifies SWELL1-mediated D-2HG export as a mechanism for immune evasion and metabolic fitness in IDH-mutant gliomas, showing that inhibiting this pathway can suppress tumor growth and enhance immune response.

Expanding the Ligandable Chemical Space of OTUB1 through Discovery of a Four-Membered-Ring Recruiter Chemotype

The paper identifies a new four-membered-ring chemotype that selectively binds OTUB1, expands its ligandable chemical space, and enables the development of next-generation DUBTACs.

TEAD1 signaling modulates adrenal chromaffin maturation

The paper identifies TEAD1 signaling as a critical regulator of chromaffin cell differentiation and function, and shows that SB699551 modulates this signaling to suppress pheochromocytoma cell proliferation.

Coordinated subpocket engagement underlies nitazene potency at the μ-opioid receptor.

The paper identifies structural determinants of nitazene potency at the μ-opioid receptor using functional assays, quantum mechanics, and molecular dynamics simulations.

MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, enhances tumor-microglia crosstalk, and drives immune checkpoint blockade efficacy.

This study identifies the MAPK/ERK pathway as a key regulator of glioma susceptibility to immune checkpoint blockade, showing it modulates interferon responses, T cell recruitment, and tumor-microglia interactions.

SNAP MRI Reveals Association Between Distal Cerebral Arterial Flow and Cognitive Function in an Aging Population

This study shows that SNAP MRI measurements of distal cerebral arterial flow correlate with cognitive function in aging individuals, suggesting their value in assessing cerebrovascular health.

THOC1 complexes with SIN3A to regulate R-loops and promote glioblastoma progression

This study identifies THOC1 as a driver of glioblastoma progression by interacting with SIN3A to regulate R-loops and telomere stability.

Identification and characterization of emNagⅡ, a novel β-1,2-N-acetylglucosaminidase from Elizabethkingia meningoseptica

This paper identifies and characterizes emNagⅡ, a β-1,2-N-acetylglucosaminidase from Elizabethkingia meningoseptica that removes β-1,2-linked N-acetylglucosamine from living cell surfaces.

Research on crop phenotype prediction using SNP context and whole-genome feature embedding

This paper introduces SNP-context and whole-genome feature embeddings using DNABERT-2 for crop phenotype prediction, showing improved accuracy over traditional methods for traits with varying heritability.

Targeting CHEK2-YBX1&YBX3 regulatory hub to potentiate immune checkpoint blockade response in gliomas

This study identifies the CHK2-YBX1&YBX3 hub as an immunosuppressive mechanism in gliomas and shows that targeting it with SU056 enhances immune checkpoint blockade efficacy.

The expression of IL-35 in the prophase of liver failure and its preliminary exploration for the mechanism of immunoregulation by IL-35 and glucocorticoids

The paper determines the optimal dose of concanavalin for a liver failure mouse model and investigates the role of IL-35 and glucocorticoids in immunoregulation and disease progression.

Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord

The paper uses single nucleus RNA sequencing to identify diverse cholinergic neuron types in the adult mouse spinal cord, revealing distinct transcriptomic classes of visceral and skeletal motor neurons.

Tbx1 interacts genetically with Vegfr3 to regulate cardiac lymphangiogenesis in mice

This study shows that Tbx1 and Vegfr3 interact genetically to regulate cardiac lymphangiogenesis, with dosage balance required for proper vessel development.