Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications
Rafael F. Guerrero, Tandin Dorji, Ra’Mal M. Harris, Matthew D. Shoulders, C. Brandon Ogbunugafor
The paper introduces two metrics to quantify drug-target interactions across genetic variants and drug panels, and analyzes their interactions in a beta-lactamase and beta-lactam drug system.
eLife · Jun 4, 2024Peer-reviewedSystems Biology