C. Brandon Ogbunugafor

This study examines how environmental context influences empirical fitness seascapes across multiple scales, finding system-specific changes in their qualitative and quantitative features.

This paper develops a geometric framework to show how energetic constraints shape ecological network diversity, revealing a unimodal relationship between energy supply and biodiversity.

This study examines how temperature and surface chemistry interact to affect viral survival and reproduction, finding non-additive effects that decouple stability from replication.

The paper investigates environment-by-environment interactions (ExE) across genetic backgrounds (ExExG) in yeast, showing that drug combinations vary in effectiveness among mutants and introducing a new predictive framework.

The study assesses the humoral innate immune response of wild Florida Mottled Ducks to E. coli using a bactericidal assay and finds no significant relationship between immune capacity and measured covariates.

This study shows relaxed selection can speed the evolution of complex adaptations requiring multiple deleterious steps by enabling faster valley crossing in evolutionary landscapes.

The paper introduces two metrics to quantify drug-target interactions across genetic variants and drug panels, and analyzes their interactions in a beta-lactamase and beta-lactam drug system.

The paper investigates factors associated with a 2021 avian mortality event, finding that birds consuming supplemental feed and ground foragers were significantly represented in affected samples.

The paper uses metagenomic sequencing to investigate a wildlife mortality event in songbirds, finding no single pathogen but highlighting the utility of metagenomics in such investigations.

The paper analyzes how mutations affect biophysical subspaces of DHFR enzymes, revealing epistatic and pleiotropic interactions across different phenotypic dimensions.

The paper develops a mathematical framework to model waterborne and indirectly transmitted infections and applies it to cholera and hepatitis C to show the importance of environmental reservoir dynamics.

The paper investigates how proteostasis machinery influences higher-order epistasis in antibiotic resistance traits across different bacterial species.

This study shows that genotypic context affects the speed and direction of evolution in antimicrobial resistance by altering fitness landscape topography through simulations and engineered bacterial strains.