Author

Ra’Mal M. Harris

Massachusetts Institute of TechnologyORCID 0000-0002-9537-371XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein design· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Matthew D. ShouldersiD· 2 shared Amanuella A. Mengiste· 1 shared Amit ChoudharyiD· 1 shared Andrew L. Sabol· 1 shared Anton M. Barybin· 1 shared C. Brandon OgbunugaforiD· 1 shared Cale M. Locicero· 1 shared Chaiheon Lee· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

Matthew D. ShouldersORCID

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2 papers

Recent·Most cited

Synthetic BiologyProceedings of the National Academy of SciencesPeer-reviewedMay 26, 2026

Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells

Andrew L. Sabol, Amanuella A. Mengiste, Prashant Singh…·Matthew D. Shoulders

This paper develops CRISPR-MACE, a platform for continuous directed evolution of CRISPR-Cas9 in human cells, generating variants with enhanced DNA binding and resistance to AcrIIA4.

1 citation

humanCRISPR screen

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Systems BiologyeLifePeer-reviewedJun 4, 2024

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

Rafael F. Guerrero, Tandin Dorji, Ra’Mal M. Harris…·C. Brandon Ogbunugafor

The paper introduces two metrics to quantify drug-target interactions across genetic variants and drug panels, and analyzes their interactions in a beta-lactamase and beta-lactam drug system.

2 citations

statistical modelbenchmarking

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