Rafael F. Guerrero

A network perspective on the evolution of hybrid incompatibilities

The paper extends DMI models with a network approach to study how gene interaction network structure influences the evolution of hybrid incompatibilities, finding that network density and topology significantly affect incompatibility accumulation and clustering.

An X-linked sex determination mechanism in cannabis and hop

The paper identifies an X-linked sex determination mechanism in cannabis and hop, showing that an X-linked gene involved in ethylene biosynthesis controls female inflorescence development, while the Y chromosome lacks clear sex-determining genes.

Network Ontology Transcript Annotation Identifies Genetic Signals Underlying Sex Determination.

The paper uses Nota to identify genes involved in cannabis sex determination by analyzing transcriptomic data from silver-treated plants.

The geometry of dominance shows broad potential for stable polymorphism under antagonistic pleiotropy

The paper challenges the notion that stable polymorphism under antagonistic pleiotropy is rare, showing that it is possible under various models without requiring dominance reversal or weak selection.

Gonadal Transcriptome Differences Between the Sexes in Wild Caught Southern Flounder (Paralichthys lethostigma) During a Critical Development Period

This study identifies genes related to sex determination in southern flounder using transcriptome analysis of wild-caught juveniles with differing sex ratios.

Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus

This study investigates the genetic associations of early pregnancy C-reactive protein (CRP) levels with gestational diabetes mellitus (GDM) using maternal and offspring genome-wide association studies (GWAS).

Mixed outcomes in recombination rates after domestication: Revisiting theory and data

The paper examines recombination rate changes in domesticated species compared to their wild ancestors, finding mixed results across chicken, sheep, and goats.

Trophic level associated gut length divergence evolved under sexual conflict in Lake Malawi cichlids

This study identifies genetic factors underlying gut length variation in Lake Malawi cichlids, showing sex-specific quantitative trait loci and epistatic interactions linked to trophic level differences and sexual conflict.

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

The paper introduces two metrics to quantify drug-target interactions across genetic variants and drug panels, and analyzes their interactions in a beta-lactamase and beta-lactam drug system.

Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance

The paper analyzes how mutations affect biophysical subspaces of DHFR enzymes, revealing epistatic and pleiotropic interactions across different phenotypic dimensions.

The Ortholog Conjecture Revisited: the Value of Orthologs and Paralogs in Function Prediction

This study revisits the ortholog conjecture by analyzing function prediction accuracy using orthologs and paralogs across two species pairs, finding strong evidence against the conjecture.

Proteostasis environment shapes higher-order epistasis operating on antibiotic resistance

The paper investigates how proteostasis machinery influences higher-order epistasis in antibiotic resistance traits across different bacterial species.

Genotypic context modulates fitness landscapes: Effects onthe speed and direction of evolution for antimicrobialresistance

This study shows that genotypic context affects the speed and direction of evolution in antimicrobial resistance by altering fitness landscape topography through simulations and engineered bacterial strains.

The Moose of Isle Royale: An Unnatural Condition?

The paper examines the historical population dynamics of moose on Isle Royale and discusses the impact of wolf reintroduction and potential extinction on the ecosystem.