The cytosolic PRMT5-CDK4 complex impairs cell cycle kinase signaling
Sarah Masser, Tanja Lotteritsch, Anton Emil Ludwig, Bettina Halwachs, Elisabeth Annerer, Marion Mußbacher, Ulrich Stelzl
The paper identifies PRMT5-CDK4 complex formation as a non-enzymatic regulator of cell cycle signaling, showing it modulates CDK4 interactions and mimics CDK4 inhibition.
bioRxiv · Dec 14, 2025 · PreprintSystems Biology