Copy number of the blaNDM-1 gene (New Delhi metallo-β-lactamase-1) and meropenem susceptibility in Enterobacterales: Consideration for treatment with meropenem?
Amrita Bhattacharjee, Soumalya Banerjee, Sanjib Das, Tanusree Ray, Nibendu Mondal, Agniva Majumdar, Sulagna Basu
This study investigates why some blaNDM-1-positive Enterobacterales are susceptible to meropenem despite carrying the gene, finding lower gene copy numbers and expression correlate with reduced MIC values, supporting meropenem's efficacy in these cases.
bioRxiv · Sep 3, 2025 · PreprintMicrobiology