Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal Nets
Sverre Grødem, Elise Holter Thompson, Malin Benum Røe, Guro Helén Vatne, Ingeborg Nymoen, Alessio Paolo Buccino, Tarjei Madland, Torkel Hafting, Marianne Fyhn, Kristian Kinden Lensjø
This paper investigates the role of Aggrecan in PV+ interneurons by creating a conditional knockout model and finds that its absence does not affect electrophysiological properties but alters behavioral strategies and anxiety levels.
bioRxiv · Mar 20, 2024 · PreprintNeuroscience