Sverre Grødem

Raster photostimulation of large-scale neural populations

This paper introduces a new system for activating and recording thousands of neurons over a large field-of-view with pixel-level precision.

Large-scale volumetric two-photon calcium imaging enables cellular-resolution mesoscopic mapping of marmoset cortical areas

The paper develops a method for large-scale volumetric calcium imaging in marmoset brains, revealing fine-grain tuning properties and columnar organization in auditory and visual cortices.

Perineuronal nets reflect a continuum of fast-spiking specialization in adult parvalbumin interneurons

The paper identifies a transcriptional continuum in parvalbumin interneurons based on perineuronal net status, linking it to fast-spiking specialization and plasticity.

Spatial predictive coding in visual cortical neurons

The paper tests whether mismatch responses in visual cortex are due to spatial or temporal predictive coding by manipulating visual stimuli in mice.

Brainstem sensing of multiple body signals during food consumption

The paper maps neural activity in the mouse brainstem during food consumption, showing how different body signals are integrated across spatially clustered neurons.

Task and Behavior-Related Variables Are Encoded by the Postrhinal and Medial Entorhinal Cortex During Non-Spatial Associative Learning

This study shows that MEC and POR encode task- and behavior-related variables during non-spatial learning, with MEC showing stronger within-cluster correlations and anatomical organization.

Cortical Reactivations Modulated by Local InhibitoryCircuits Mediate Memory Consolidation

The paper shows that reactivations in the lateral visual cortex are essential for visual association learning consolidation, with inhibitory neuron manipulation reducing cue-specific reactivations and learning.

Deciphering the Role of Aggrecan in Parvalbumin Interneurons: Unexpected Outcomes from a Conditional ACAN Knockout That Eliminates WFA+ Perineuronal Nets

This paper investigates the role of Aggrecan in PV+ interneurons by creating a conditional knockout model and finds that its absence does not affect electrophysiological properties but alters behavioral strategies and anxiety levels.

An updated suite of viral vectors for in vivo calcium imaging using local and retro-orbital injections

The paper develops and tests new viral vectors for systemic and local delivery of GECIs to enable brain-wide calcium imaging without transgenic mouse lines.