Drosophila midgut tumor-induced insulin resistance systemically remodels lymph gland hematopoiesis during cancer cachexia
Ujjayita Chowdhury, Gauri Panzade, Priya Neelesh Karnik, Pushkar Birwadkar, Tashu Wadhwa, Rohan Jayant Khadilkar
This study shows that tumor-induced insulin resistance in Drosophila remodels lymph gland hematopoiesis through ImpL2 overexpression and disrupts the Insulin-Wingless signaling axis.
FEBS Journal · Sep 26, 2026Peer-reviewedCancer Biology