Rohan Jayant Khadilkar

Drosophila midgut tumor-induced insulin resistance systemically remodels lymph gland hematopoiesis during cancer cachexia

This study shows that tumor-induced insulin resistance in Drosophila remodels lymph gland hematopoiesis through ImpL2 overexpression and disrupts the Insulin-Wingless signaling axis.

Developmental regulation of progenitor aging shapes long-term intestinal homeostasis in Drosophila

This study shows that manipulating cellular aging in larval Drosophila midgut progenitors affects long-term intestinal aging and homeostasis in adults.

Mitocurcumin mediated redox disruption and metabolic rewiring induces tumor regression in Drosophila intestinal stem cell tumors

This study shows Mitocurcumin disrupts redox balance and rewires metabolism in Drosophila intestinal tumors, leading to tumor regression and extended lifespan.

Bendless-mediated K63 ubiquitination modulates cellular signalling to regulate Drosophila hematopoiesis

This study investigates how Bendless-mediated K63 ubiquitination regulates Drosophila hematopoiesis by modulating Wingless and JNK signaling pathways.

Modulation of cellular ageing regulates Integrated Stress Response signalling to control blood cell homeostasis

This study investigates how modulating cellular ageing affects blood cell homeostasis in Drosophila larval lymph glands by examining the role of the Integrated Stress Response pathway.

Gcn5 and mTORC1 mediated regulation of autophagy controls Drosophila blood cell homeostasis

This study shows that Gcn5 and mTORC1 regulate autophagy in Drosophila blood cell homeostasis through genetic and chemical perturbation analysis.