Skeletal muscle aging drives sex- and compartment-specific protein insolubility that is modifiable by proteostasis-directed treatments
Paulo H.C. Mesquita, Tanisha Goyal, Xiayou Ren, Joanna Papinska, Michael E. Taylor, Taylor J. Lundgren, Zachary R. Hettinger, Benjamin F. Miller
This study investigates age-related changes in protein insolubility in skeletal muscle and shows that these changes are sex- and compartment-specific and can be modified by exercise and rapamycin.
bioRxiv · Nov 9, 2026 · PreprintPhysiology