Host immune responses after suprachoroidal delivery of AAV8 in nonhuman primate eyes
Sook Hyun Chung, Iris Natalie Mollhoff, Alaknanda Mishra, Tzu-Ni Sin, Taylor Ngo, Thomas A. Ciulla, Paul A. Sieving, Sara M. Thomasy, Glenn C. Yiu
This study examines immune responses to AAV8 delivery via suprachoroidal route in nonhuman primates, finding mild inflammation and immune cell infiltration with reduced systemic viral capsid antibody responses.
Human Gene Therapy · Jan 15, 2021Peer-reviewedGenetics