Author

Paul A. Sieving

University of California, DavisORCID 0000-0002-2918-577XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:non-human primate· 2 Assay:ATAC-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:Hi-C· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Alaknanda MishraiD· 1 shared Bilge Esin ÖztürkiD· 1 shared Brett C. Hogle· 1 shared Fabian Köchl· 1 shared Franco Revelant· 1 shared Glenn C. YiuiD· 1 shared Haley N. JanowitziD· 1 shared Hamzah AweidahiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperGenetics

Alaknanda MishraORCID

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2 papers

Recent·Most cited

Structural dynamics insights into principles underlying the fitness of new broadly potent AAVs

Molly E. Johnson, Bilge Esin Öztürk, Thomas H. Tugwell, Maryl Lambros, Haley N. Janowitz, Keevon Flohr, Morgan Sedorovitz, Laura Campello, J Hartung, Brett C. Hogle, Megan E. Gillespie, Hannah Schriever, Hamzah Aweidah, Janis Koester, Inga Clausen, , Leah C. Byrne

The paper develops a new AAV engineering workflow, scAAVengr-Hunt, to create potent vectors and identifies a structural mechanism underlying their broad species and tissue potency.

bioRxiv · May 17, 2026 · PreprintBioengineering

Host immune responses after suprachoroidal delivery of AAV8 in nonhuman primate eyes

Sook Hyun Chung, Iris Natalie Mollhoff, Alaknanda Mishra, Tzu-Ni Sin, Taylor Ngo, Thomas A. Ciulla, Paul A. Sieving, Sara M. Thomasy, Glenn C. Yiu

This study examines immune responses to AAV8 delivery via suprachoroidal route in nonhuman primates, finding mild inflammation and immune cell infiltration with reduced systemic viral capsid antibody responses.

Human Gene Therapy · Jan 15, 2021Peer-reviewedGenetics