Modulation of the sensitivity to ruxolitinib-mediated JAK2 inhibition by mutationally activated SHP2 exhibits cell context dependency in pre-clinical models of myeloproliferative neoplasms
Tegan M. Rowsell, Garima Pandey, Lucia Mazzacurati, Narmin E. Amin, Gary W. Reuther
This study shows that an activating SHP2 mutation in MPN cell models alters sensitivity to JAK2 inhibition, with context-dependent effects observed in different cell lines.
bioRxiv · Aug 20, 2026 · PreprintCancer Biology