Author

Tek Hyung Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Songming LiuiD· 2 shared Trang Nguyen· 2 shared Li zu yi· 1 shared Longfei Cong· 1 shared Per Jr GreiseniD· 1 shared Roger ShekiD· 1 shared Sagar D. KhareiD· 1 shared Yi LiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBioengineering

Songming LiuORCID

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2 papers

Recent·Most cited

Combinatorial Protein Language Model-Guided Engineering of TEV Protease for Enhanced Stability and Production

Tek Hyung Lee, Songming Liu, Yifan Li, Trang Nguyen, Zhaoren He, Sagar D. Khare, Li zu yi

This study uses three protein language models to engineer TEV protease variants with improved stability and production, showing high efficiency with fewer designs.

bioRxiv · Dec 23, 2025 · PreprintBioengineering

Computational Design of Soluble CCR8 Analogues with Preserved Antibody Binding

Trang Nguyen, Songming Liu, Yifan Li, Longfei Cong, Roger Shek, Tek Hyung Lee, Yi Li, Per Jr Greisen

This paper computationally designs soluble CCR8 analogues that retain native antibody binding, achieving a 62% success rate with preserved structural and functional properties.

bioRxiv · Aug 18, 2025 · PreprintBioengineering