Trang Nguyen

Genomic atlas of cardiac and adiposity imaging phenotypes

The paper constructs a genomic atlas of cardiac and adiposity imaging phenotypes using whole-genome sequencing data from UK Biobank, identifying genetic associations and polygenic scores linked to cardiometabolic diseases.

Epilepsy-Associated SCN2A-L1342P Mutation Drives Network Hyperexcitability and Widespread Transcriptomic Changes in Human Cortical Organoids

This study investigates the effects of the SCN2A-L1342P mutation in human cortical organoids, finding increased neuronal excitability, enhanced synaptic transmission, and transcriptomic changes related to synaptic and developmental pathways.

Combinatorial Protein Language Model-Guided Engineering of TEV Protease for Enhanced Stability and Production

This study uses three protein language models to engineer TEV protease variants with improved stability and production, showing high efficiency with fewer designs.

De Novo Computational Design of VHH Nanobodies Against LGR5

This paper presents a computational pipeline for designing VHH nanobodies against LGR5 without structural templates, resulting in high-affinity, stable binders validated by cryo-EM.

The G-protein coupled receptor GPR34 maintains the homeostatic state of microglia and restrains the disease-associated microglial response in an Alzheimers disease model

This study shows that GPR34 maintains microglial homeostasis and limits disease-associated microglial responses in Alzheimer's disease models.

An ancestry-enriched HNF4A variant and GP2 reveal distinct mechanisms of type 2 diabetes in exome-wide study of 13,674 cases and 41,024 controls

The paper identifies ancestry-specific T2D risk variants in South Asian populations through exome-wide association study and functional validation.

Computational Design of Soluble CCR8 Analogues with Preserved Antibody Binding

This paper computationally designs soluble CCR8 analogues that retain native antibody binding, achieving a 62% success rate with preserved structural and functional properties.

Genome-Wide Comparison Of Toxigenic And Non-Toxigenic Corynebacterium diphtheriae Isolates Identifies Differences In The Pan Genomes Between Respiratory And Cutaneous Strains

This study compares toxigenic and non-toxigenic Corynebacterium diphtheriae isolates to identify genomic differences between respiratory and cutaneous strains, highlighting potential virulence factors.