Author

Zhaoren He

University of California San DiegoORCID 0000-0001-5521-1460Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Cornelis MurreiD· 2 shared Matthew Denholtz· 2 shared Alexandra BortnickiD· 1 shared Hanbin Lu· 1 shared Kenian Chen· 1 shared Li zu yi· 1 shared Megan AubreyiD· 1 shared Sagar D. KhareiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersGenomics

Cornelis MurreORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintDec 23, 2025

Combinatorial Protein Language Model-Guided Engineering of TEV Protease for Enhanced Stability and Production

Tek Hyung Lee, Songming Liu, Yifan Li…·Li zu yi

This study uses three protein language models to engineer TEV protease variants with improved stability and production, showing high efficiency with fewer designs.

DOI 10.64898/2025.12.19.695604

protein sequencedeep learning

𝕏 PostBluesky

GenomicsGenes & DevelopmentPeer-reviewedFeb 1, 2020

Upon microbial challenge human neutrophils undergo rapid changes in nuclear architecture to orchestrate an immediate inflammatory gene program

Matthew Denholtz, Yina Zhu, Zhaoren He…·Cornelis Murre

This study shows that human neutrophils reposition inflammatory genes to a transcriptionally permissive compartment within hours of microbial exposure, enabling rapid transcriptional responses.

39 citations

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivPreprintApr 7, 2018

An inter-chromosomal transcription hub activates the unfolded protein response in plasma cells

Alexandra Bortnick, Zhaoren He, Megan Aubrey…·Cornelis Murre

DOI 10.1101/295915

mousebulk RNA-seq

𝕏 PostBluesky