A cell-matrix interaction regulates the undifferentiated state and self-renewal capacity of avian primordial germ cells
Kennosuke Ichikawa, Yuzuha Motoe, Tenkai Watanabe, Ryo Ezaki, Mei Matsuzaki, Hiroyuki Horiuchi, Mike J. McGrew
This study shows that cell-matrix interactions regulate self-renewal and undifferentiated state of chicken primordial germ cells, with excessive interactions causing somatic conversion.
bioRxiv · Jan 28, 2025 · PreprintDevelopmental Biology