Mike J. McGrew

This study identifies CSF1R-dependent macrophage subpopulations in chickens and shows their critical role in B cell development and function.

This study establishes a long-term culture system for rock dove primordial germ cells, enabling germline manipulation and conservation applications.

This study investigates the role of IL10 in avian mucosal immunity by generating IL10-deficient chickens, showing altered microbiome composition and enhanced pathogen clearance with increased inflammation.

FuChi is a new Fucci-based system in chickens that accurately tracks cell cycle phases in vivo, improving upon existing models by distinguishing all phases and enabling detailed developmental studies.

This study identifies miR-2954 as a male-essential microRNA critical for avian sex chromosome dosage compensation, showing its role in balancing gene expression in males and females.

The paper examines why chicken embryos are underutilized as a replacement model in biomedical research despite their potential, using UK grant data from 2017-2023.

This study shows that cell-matrix interactions regulate self-renewal and undifferentiated state of chicken primordial germ cells, with excessive interactions causing somatic conversion.

The paper generates a Netrin-1 fluorescent reporter chicken line to study molecular signatures during optic fissure closure and identifies new markers and pathways for developmental tissue fusion.

The paper shows estrogen reduces DMRT1 protein levels in female chicken gonads during ovarian development, suggesting estrogen signaling regulates primary sex determination.

The paper describes a low-tech method for cryopreserving chicken embryonic gonads to conserve genetic diversity for poultry breeding.

This study generates transgenic songbirds by efficiently modifying zebra finch primordial germ cells with lentiviral vectors.

This paper introduces a method to transfer genetic alleles between chicken breeds using SDS mating to create pure breeds with desired traits.