The MARK2 kinase acts as a gatekeeper of CD28-dependent co-stimulation in T cells
Hermine Ferran, Federico Marconi, Stéphanie Dogniaux, Christel Goudot, Aymeric Zellner, Théo Cools, Thibaut Larcher, Élise Brisebard, Noémie Paillon, Frédéric FIORE, CIPHE-GEMTISortium investigators, Claire Hivroz, Laurence Bataille
This study identifies MARK2 as a gatekeeper of CD28-dependent co-stimulation in T cells, showing it restricts metabolic and transcriptional programs normally driven by CD28.
bioRxiv · Oct 13, 2025 · PreprintImmunology