Thibaut Larcher

Intracellular accumulation of AAV6 genomes governs microglia reactivity and the inflammatory response in retinal gene therapy

This study shows that intracellular accumulation of AAV6 genomes in microglia drives reactivity and inflammation in retinal gene therapy.

Nipah virus Malaysia and Bangladesh strain-induced pathogenesis in mice lacking type I interferon receptor signaling

This study compares the pathogenesis of NiV-Malaysia and NiV-Bangladesh strains in IFNAR KO mice, showing differential outcomes based on infection route and strain.

The MARK2 kinase acts as a gatekeeper of CD28-dependent co-stimulation in T cells

This study identifies MARK2 as a gatekeeper of CD28-dependent co-stimulation in T cells, showing it restricts metabolic and transcriptional programs normally driven by CD28.

Advancing Liver Gene Therapy: Enhanced Transduction with GalNAc-Bioconjugated rAAV Capsids

This study enhances liver gene therapy by conjugating GalNAc to rAAV capsids, improving transduction efficiency in mice while reducing required dosages.

Flagellin aerosol administration improves the efficacy of antibiotic treatment in Actinobacillus pleuropneumoniae infected pigs

This study shows that combining aerosolized FLAMOD with subtherapeutic penicillin G improves bacterial clearance and reduces lung lesions in pigs infected with Actinobacillus pleuropneumoniae.

The effects of iron deficient and high iron diets on SARS-CoV-2 lung infection and disease

This study investigates the effects of iron deficiency and overload on SARS-CoV-2 lung infection in mice, finding modest inflammatory changes but no significant disease exacerbation.

Conserved RNA-binding protein interactions mediate syntologous lncRNA functions

The paper shows that conserved RNA-binding protein interactions mediate the function of syntologous lncRNAs despite lacking sequence similarity.