Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntingtons disease
Jillian Belgrad, Todd M. Greco, Ellen Sapp, Ashley Summers, Daniel O’Reilly, Eric Luu, Josiah E. Hutton, Nozomi Yamada, Hassan H. Fakih, Raymond C. Furgal, Dimas Echeverria, Nicholas McHugh, Brianna M. Bramato, Chantal Ferguson, Samuel R. Hildebrand, , Anastasia Khvorova
The paper uses RNAi to identify dose-dependent MMR gene modulators of somatic instability and proteome changes in HD mouse models.
bioRxiv · Jun 25, 2026 · PreprintNeuroscience