Author
University of Massachusetts Chan Medical School
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
6 papers
Recent·Most cited
Jillian Belgrad, Todd M. Greco, Ellen Sapp…·Anastasia Khvorova
The paper uses RNAi to identify dose-dependent MMR gene modulators of somatic instability and proteome changes in HD mouse models.
Jillian Belgrad, Ashley Summers, Samuel R. Hildebrand…·Anastasia Khvorova
The paper compares somatic CAG expansion and siRNA responses in C57BL/6 and FVB BAC-CAG HD mouse models, finding comparable expansion and MSH3-targeted siRNA efficacy.
Theodore Carrigan-Broda, Luca F. R. Gebert, Samuel R. Hildebrand…·Ken Yamada
This study identifies organyl 5'-phosphate mimics that enhance AGO2 binding and metabolic stability by interacting with a hydrophobic pocket in the MID domain.
Jillian Belgrad, Ashley Summers, Christian Landles…·Anastasia Khvorova
This study shows that combining RNAi to silence MSH3 and HTT reduces huntingtin inclusions and restores gene expression in HD mice.
Alexandra Weiss, James W. Gilbert, Iris Valeria Rivera Flores…·Anastasia Khvorova
The paper shows that silencing SOD1 with optimized di-siRNA extends survival and prevents disease progression in ALS mice.
Rachael Miller, Joseph D. Paquette, Alexandra Barker…·Neil Aronin M. D
This study shows adding high concentrations of Ca2+ and Mg2+ to oligonucleotide formulations prevents acute neurotoxicity in CNS delivery without affecting efficacy.