Todd M. Greco

The paper develops targeted mass spectrometry assays to quantify DNA repair and handling proteins in Huntington's disease models and finds HTT influences their abundance and interactions.

The paper uses RNAi to identify dose-dependent MMR gene modulators of somatic instability and proteome changes in HD mouse models.

The paper shows that viral resistance in human skin cells is inherited through cellular lineages and preserved across generations.

The paper identifies striatum-selective molecular interactions of huntingtin using multi-epitope assays and models, revealing its role in transcriptional regulation and disease mechanisms.

This study shows that ARPE-19 cells fail to initiate type-I interferon signaling in response to HCMV infection due to low expression of key pattern recognition receptors and signaling molecules.

The paper uses quantitative proteomics to study murine embryonic heart development and identifies the mevalonate pathway's role in cardiomyocyte proliferation.

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.

This study uses consensus clustering of HSV1 protein interaction networks to uncover evolutionary links between herpesviruses and bacteriophages, identifying pUS10 as a potential evolutionary vestige.