Josiah E. Hutton

The paper develops targeted mass spectrometry assays to quantify DNA repair and handling proteins in Huntington's disease models and finds HTT influences their abundance and interactions.

The paper uses RNAi to identify dose-dependent MMR gene modulators of somatic instability and proteome changes in HD mouse models.

The paper identifies striatum-selective molecular interactions of huntingtin using multi-epitope assays and models, revealing its role in transcriptional regulation and disease mechanisms.

The paper identifies sex-specific transcriptomes and proteomes in cardiac tissue, showing that sex differences are established before gonad formation through post-transcriptional mechanisms and hormonal/sex chromosomal factors.