Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery
Xuduo Li, Ipsita Krishnamurthy, Nitesh Mishra, Nicole E. James, Rohan Roy Chowdhury, Sean Callaghan, Anjali Somanathan, Gabriel Avillion, Khaled Amereh, Tharunika Sekar, Prabhgun Oberoi, Yuxin Zhu, Jonathan L. Torres, Wen-Hsin Lee, Joel D. Allen, , Raiees Andrabi
The paper designs native-like HIV Env single-chain trimers (SCTs) that are stable, immunogenic, and compatible with vaccine delivery methods.
bioRxiv · Oct 25, 2025 · PreprintImmunology