Khaled Amereh

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization

The paper shows that early clonal dominance in B-cell precursors after vaccination predicts the breadth of HIV-neutralizing antibodies in rhesus macaques.

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery

The paper designs native-like HIV Env single-chain trimers (SCTs) that are stable, immunogenic, and compatible with vaccine delivery methods.

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.

Rapid acquisition of HIV-1 neutralization breadth in a rhesus V2 apex germline antibody mouse model after a single bolus immunization

This study shows that a single immunization with a germline-targeting trimer can induce broad HIV-1 neutralizing antibodies in a rhesus macaque bnAb mouse model.

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.