Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity
Ronan Broderick, Veronica Cherdyntseva, Jadwiga Nieminuszczy, Eleni Dragona, Maria Kyriakaki, Theodora Evmorfopoulou, Sarantis Gagos, Wojciech Niedźwiedź
This study identifies EXD2's role in regulating ALT telomere repair pathways by processing replication forks, revealing its importance in cancer survival and potential as a therapeutic target.
Nature Communications · Apr 27, 2023Peer-reviewedMolecular Biology