Author

Jadwiga Nieminuszczy

Institute of Cancer ResearchORCID 0000-0003-4672-9684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Wojciech NiedźwiedźiD· 4 shared Peter R. MartiniD· 2 shared Ronan BroderickiD· 2 shared Αλεξάνδρα ΚανέλλουiD· 2 shared Amélie ZachayusiD· 1 shared Andrés AguileraiD· 1 shared Antony W. OliveriD· 1 shared Beth L. WoodwardiD· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersMolecular Biology

Wojciech NiedźwiedźORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ

Peter R. Martin, Jadwiga Nieminuszczy, Zuza Kozik, Nihal Jakub, Maxime Lecot, Julia Vorhauser, Karen A. Lane, Αλεξάνδρα Κανέλλου, Jörg Mansfeld, Laurence H. Pearl, Antony W. Oliver, Jessica A. Downs, Jyoti Sharma Choudhary, M.W. Day, Wojciech Niedźwiedź

The paper identifies the CIP2A-TOPBP1 axis as a regulator of mitotic DNA repair pathways, showing it promotes MiDAS and MMEJ through distinct mechanisms.

bioRxiv · Nov 12, 2024 · PreprintMolecular Biology

Actin nucleators safeguard replication forks by limiting nascent strand degradation

Jadwiga Nieminuszczy, Peter R. Martin, Ronan Broderick, Joanna Krwawicz, Αλεξάνδρα Κανέλλου, Camelia Mocanu, Vicky Bousgouni, Charlotte Smith, Kuo‐Kuang Wen, Beth L. Woodward, Chris Bakal, Fiona Shackley, Andrés Aguilera, Grant S. Stewart, Yatin M. Vyas, Wojciech Niedźwiedź

The paper identifies actin nucleators as essential for protecting replication forks by modulating RPA activity and preventing ssDNA degradation during replicative stress.

Nucleic Acids Research · May 24, 2023Peer-reviewedMolecular Biology

Pathway choice in the alternative telomere lengthening in neoplasia is dictated by replication fork processing mediated by EXD2's nuclease activity

Ronan Broderick, Veronica Cherdyntseva, Jadwiga Nieminuszczy, Eleni Dragona, Maria Kyriakaki, Theodora Evmorfopoulou, Sarantis Gagos, Wojciech Niedźwiedź

This study identifies EXD2's role in regulating ALT telomere repair pathways by processing replication forks, revealing its importance in cancer survival and potential as a therapeutic target.

Nature Communications · Apr 27, 2023Peer-reviewedMolecular Biology

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

Jérémy Sandoz, Max Cigrang, Amélie Zachayus, Philippe Catez, Lise‐Marie Donnio, Clémence Elly, Jadwiga Nieminuszczy, Pietro Berico, Cathy Braun, Sergey Alekseev, Jean‐Marc Egly, Wojciech Niedźwiedź, Giuseppina Giglia‐Mari, Emmanuel Compe, Frédéric Coin

The paper shows that EXD2 nuclease degrades nascent mRNAs during genotoxic stress, enabling transcription recovery after DNA repair.

Nature Communications · Jan 20, 2023Peer-reviewedMolecular Biology