Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni
Lucile Pagliazzo, Stéphanie Caby, Julien Lancelot, Sophie Salomé‐Desnoulez, Jean‐Michel Saliou, Tino Heimburg, Thierry Chassat, Katia Cailliau, Wolfgang Sippl, Jérôme Vicogne, Raymond John Pierce
This study identifies SmHDAC8 as involved in cytoskeleton organization through its interaction with SmRho1 isoforms in Schistosoma mansoni, showing acetylation of SmRho1 and disruption of actin cytoskeleton upon SmHDAC8 inhibition.
PLoS neglected tropical diseases · Nov 29, 2021Peer-reviewedMolecular Biology