Wolfgang Sippl

Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia

This study identifies SNHG29 and IGF2BP1 as a lineage-specific oncogenic circuit in AMKL, showing their dependency and therapeutic vulnerability.

Rapid proteasomal degradation of mutant feline McDonough sarcoma-like tyrosine kinase-3 overcomes tyrosine kinase inhibitor resistance of acute myeloid leukemia cells

This study develops MA191, a PROTAC degrader of FLT3-ITD, which overcomes resistance in AML cells by rapidly degrading the mutant protein and shows efficacy in vivo.

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment

The paper uses machine learning to identify novel HDAC6/AKT2 inhibitors for myeloid cancer treatment, finding compounds with potent anticancer activity.

Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

This study identifies SmHDAC8 as involved in cytoskeleton organization through its interaction with SmRho1 isoforms in Schistosoma mansoni, showing acetylation of SmRho1 and disruption of actin cytoskeleton upon SmHDAC8 inhibition.

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

This study shows that inhibiting SmLSD1 with MC3935 causes transcriptional changes and structural damage in Schistosoma mansoni, leading to parasite death.