Selective depletion of upper-layer somatostatin interneuron subtypes in schizophrenia
Nicole Endresz, Maria Eleni Fafouti, Keon Arbabi, Xiaolin Zhou, Thomas DeLong, Guillermo González‐Burgos, Laramie E. Duncan, Etienne L. Sibille, Shreejoy J. Tripathy
The paper identifies reduced SST mRNA and depletion of specific upper-layer Sst interneurons in schizophrenia using single-nucleus RNA-seq and spatial transcriptomics.
bioRxiv · Sep 22, 2026 · PreprintBioinformatics