Shreejoy J. Tripathy

Selective depletion of upper-layer somatostatin interneuron subtypes in schizophrenia

The paper identifies reduced SST mRNA and depletion of specific upper-layer Sst interneurons in schizophrenia using single-nucleus RNA-seq and spatial transcriptomics.

Spatial mapping of cellular and molecular plasticity in the maternal and postpartum mouse brain

The paper maps cellular and molecular changes in the mouse brain during pregnancy and postpartum using spatial single-cell technologies, identifying three gene expression programs and linking depression risk genes to specific brain regions.

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

Molecular architecture of human dermal sleeping nociceptors

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

Linking age changes in human cortical microcircuits to impaired brain function and EEG biomarkers

The paper links age-related cellular and synaptic changes in human cortical microcircuits to impaired brain function and EEG biomarkers using computational models and machine learning.

Hyperpolarization-activated cation channel mediated intrinsic plasticity changes underlie the malleability of with-in cell-type electrophysiological heterogeneity

The paper shows that within-cell-type electrophysiological heterogeneity is malleable and can be restored by blocking HCN currents in epilepsy models.

Spike frequency adaptation in primate lateral prefrontal cortex neurons results from interplay between intrinsic properties and circuit dynamics

The paper investigates how intrinsic spike frequency adaptation (I-SFA) and inhibitory circuit dynamics contribute to extrinsic-SFA (E-SFA) in primate lateral prefrontal cortex neurons during behavior.

Single neuron diversity supports area functional specialization along the visual cortical pathways

The paper examines single neuron diversity in primate visual cortical areas V1 and LPFC, finding differences in morphology, electrophysiology, and intrinsic bursting that may underlie functional specialization.

Perinatal Brain Injury Triggers Niche-Specific Changes to Cellular Biogeography

This study maps the regenerative response to newborn brain injury in mice using spatial transcriptomics, revealing niche-specific changes in cell states, composition, and spatial organization.

CHRNA5 links chandelier cells to severity of amyloid pathology in human aging and Alzheimer's Disease

The paper investigates CHRNA5's role in amyloid pathology in aging and Alzheimer's by analyzing genetic variants and cell-type expression in human brain tissue.

Sleep-insomnia superposition: opposing brain signatures of sleep in task-based and resting-state conditions

The paper examines correlations between task and resting-state brain signatures of sleep, cognition, and depression in over 30,000 individuals, revealing opposing neural patterns associated with insomnia and depression.

Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse Patch-seq datasets

The paper quantifies microglial contamination in Patch-seq datasets and shows its impact on electrophysiological properties of neurons.

BrainRBPedia: a resource for RNA-binding proteins relevant to neurodevelopmental disorders

BrainRBPedia is a database of 1072 RNA-binding proteins linked to neurodevelopmental disorders, with a machine learning model prioritizing RBPs for autism and intellectual disability.

Age-dependent increased sag amplitude in human pyramidal neurons dampens baseline cortical activity

The paper identifies age-related increases in sag voltage amplitude in human pyramidal neurons and shows reduced baseline firing in older neuron microcircuits.

Bulk and Single-nucleus Transcriptomics Highlight Intra-telencephalic and Somatostatin Neurons in Alzheimer's Disease

The paper identifies somatostatin and intra-telencephalic neurons as significantly associated with Alzheimer's disease using bulk and single-nucleus transcriptomics across multiple datasets.

The Neuron Phenotype Ontology: A FAIR Approach to Proposing and Classifying Neuronal Types

The paper introduces the Neuron Phenotype Ontology (NPO) to standardize neuron naming and classification across neuroscientific studies, enabling interoperability and knowledge integration.

LaminaRGeneVis: a tool to visualize gene expression across the laminar architecture of the human neocortex

LaminaRGeneVis visualizes gene expression across human neocortex layers using harmonized bulk, single-nucleus, and spatial RNA sequencing data.

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits

The paper models human cortical microcircuits to show reduced inhibition in depression impairs stimulus processing by increasing baseline activity and reducing signal-to-noise ratio.

Chrna5 and lynx prototoxins identify acetylcholine super-responder subplate neurons

The paper identifies Chrna5-expressing super-responder subplate neurons using transgenic mice and single-cell transcriptomics, revealing unique lynx prototoxin gene expression and potential therapeutic targets for attention disorders.

Autism spectrum disorder trios from consanguineous populations are enriched for rare biallelic variants, identifying 32 new candidate genes

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

The paper characterizes electrophysiological diversity among human cortical pyramidal neurons by analyzing sag currents and frequency preferences across different cortical layers.

Single-nucleus RNA sequencing shows convergent evidence from different cell types for altered synaptic plasticity in major depressive disorder.

The paper uses single-nucleus RNA sequencing to identify gene expression changes in specific cell types associated with major depressive disorder.

Transcriptomic correlates of electrophysiological and morphological diversity within and across neuron types

The paper identifies gene expression correlations with electrophysiological and morphological traits across neuron types, distinguishing class-driven from within-class relationships.

A critical assessment of single-cell transcriptomes sampled following patch-clamp electrophysiology

This study assesses patch-seq, showing technical artifacts in single-cell transcriptomes and proposing a marker gene-based approach to improve gene expression-electrophysiological feature alignment.

Consequences Of NMDA Receptor Deficiency Can Be Rescued In The Adult Brain

This study shows that restoring NMDAR function in adult mice with congenital NMDAR deficiency improves cognitive behaviors, suggesting potential for adult treatment of related disorders.

Cross-laboratory analysis of brain cell type transcriptomes with applications to interpretation of bulk tissue data

The paper compiles a database of mouse brain cell type-specific gene expression profiles, identifies novel marker genes, and demonstrates their use in analyzing bulk tissue data.

Transcriptomic Correlates Of Neuron Electrophysiological Diversity

The paper identifies 420 genes whose expression correlates with electrophysiological parameters in neurons, suggesting general principles linking gene expression to functional diversity.