Concordance of whole-genome amplified embryonic DNA with the subsequently born child
Shenglai Li, Thomas Giardina, Maria Katz, Dhruva Chandramohan, Robert Nathan Slotnick, Barry R. Behr, Noor Siddiqui, Yuntao Xia, Benjamin Podgursky
This study demonstrates high concordance between whole-genome amplified embryonic DNA and the genome of the subsequently born child, validating PGT-WGS for detecting genetic variants and polygenic risk scores.
medRxiv · Jan 12, 2024 · PreprintGenetic & Genomic Medicine