Yuntao Xia

The paper uses single-cell sequencing to uncover hidden genetic diversity in pediatric ALL that is not detected by bulk sequencing, identifying treatment-resistant clones and their associated mutations.

This study demonstrates high concordance between whole-genome amplified embryonic DNA and the genome of the subsequently born child, validating PGT-WGS for detecting genetic variants and polygenic risk scores.

This paper validates whole genome sequencing on trophectoderm biopsies of preimplantation embryos, showing high accuracy and enabling comprehensive genetic analysis.

This paper introduces PTA, a new WGA method that improves variant calling accuracy in single cells, enabling studies of genetic diversity and CRISPR off-target effects.

The paper monitors live cell fluorescence to quantify aneuploidy-inducing perturbations in lung cancer and iPS cells, revealing increased chromosome mis-segregation and rare fluorescent-null cells.

The paper shows that constricted migration causes nuclear rupture and DNA damage, which are linked to cell cycle repression and DNA repair defects in cancer cells.

The paper shows that constricted cell migration in stiff tissues causes nuclear lamina damage, DNA breaks, and loss of repair factors, leading to genomic instability.