Ablation of microglial estrogen receptor alpha predisposes to diet-induced obesity in male mice
Inmaculada Velasco, Jeremy M. Frey, Vladislav Baglaev, TRISTAN Z. JAFARI, Thomas Huang, Sophia Schwie, Olivia D. Santiago, Rachael D. Fasnacht, Joshua P. Thaler, Mauricio D. Dorfman
This study shows that microglial estrogen receptor alpha ablation in male mice leads to diet-induced obesity and insulin resistance, while females show no weight gain but mild insulin resistance.
Metabolism · Jul 2, 2026Peer-reviewedNeuroscience