Joshua P. Thaler

This study identifies IKKβ activation as a transient upstream signal triggered by efferocytosis that promotes tissue resolution through multiple downstream pathways.

This study shows that microglial estrogen receptor alpha ablation in male mice leads to diet-induced obesity and insulin resistance, while females show no weight gain but mild insulin resistance.

This study shows that CX3CL1 reduces diet-induced obesity by restoring POMC neuron function and melanocortin signaling through microglial modulation.

This study shows that microglial inflammatory activation improves glucose tolerance during diet-induced obesity, independent of body weight changes.