Mauricio D. Dorfman

Ablation of microglial estrogen receptor alpha predisposes to diet-induced obesity in male mice

This study shows that microglial estrogen receptor alpha ablation in male mice leads to diet-induced obesity and insulin resistance, while females show no weight gain but mild insulin resistance.

CX3CL1 action on microglia protects from diet-induced obesity by restoring POMC neuronal excitability and melanocortin system activity impaired by high-fat diet feeding

This study shows that CX3CL1 reduces diet-induced obesity by restoring POMC neuron function and melanocortin signaling through microglial modulation.

Microglial inflammatory activation paradoxically improves glucose tolerance during diet-induced obesity

This study shows that microglial inflammatory activation improves glucose tolerance during diet-induced obesity, independent of body weight changes.