A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Reuben A. Saunders, William E. Allen, Xingjie Pan, Jaspreet Sandhu, Jiaqi Lu, Thomas K. Lau, Karina Smolyar, Zuri A. Sullivan, Catherine G. Dulac, Jonathan S. Weissman, Xiaowei Zhuang
The paper develops a platform combining imaging and sequencing to study genetic perturbations in mouse liver, identifying regulators of hepatocyte zonation and liver unfolded protein response.
bioRxiv · Nov 18, 2024 · PreprintGenomics