Author

Karina Smolyar

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Jonathan S. WeissmaniD· 3 shared Kyle M. LohiD· 2 shared Xiaowei ZhuangiD· 2 shared Adrienne C. Philson· 1 shared Alec Wysoker· 1 shared Alicia Young· 1 shared Amir DailamyiD· 1 shared Anastasiia MasaltsevaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersDevelopmental Biology

Jonathan S. WeissmanORCID

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4 papers

Recent·Most cited

Comprehensive Lineage Tracing Maps the Landscape of Cell Fate Decisions in Mouse Embryogenesis

William N. Colgan, Luke W. Koblan, JoAnne Villagrana, Tien-Chi Jason Hou, Minming Wang, Gokul Gowri, Whitney Chandler, Leonardo A. Sepúlveda, Didar Ciftci, Karina Smolyar, Kathryn E. Yost, Alicia Young, Lars Wittler, Styliani Markoulaki, Kyle M. Loh, , Jonathan S. Weissman

Prime-editing lineage trees for 16 mouse embryos (E7.5 to E10.0, >1.4 million cells) quantify fate restriction timing, progenitor numbers and lineage relationships, and are reproducible across replicate embryos.

Cell · Oct 1, 2026Peer-reviewedDevelopmental Biology✦ In-depth digest

Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation

Lay Teng Ang, Sherry Li Zheng, Kevin J. Liu, Anastasiia Masaltseva, J. Winters, Sawan Kumar Jha, Qingqing Yin, Crystal Qian, Xiaochen Xiong, Amir Dailamy, Ellie Xi, Juan Alcocer, Daniel W. Sorensen, Richard She, Karina Smolyar, , Kyle M. Loh

The paper identifies a primed endothelial progenitor that requires VEGF/ERK inhibition to differentiate into vein endothelial cells, revealing a two-step process for vein development.

bioRxiv · Oct 11, 2025 · PreprintDevelopmental Biology

A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function

Reuben A. Saunders, William E. Allen, Xingjie Pan, Jaspreet Sandhu, Jiaqi Lu, Thomas K. Lau, Karina Smolyar, Zuri A. Sullivan, Catherine G. Dulac, Jonathan S. Weissman, Xiaowei Zhuang

The paper develops a platform combining imaging and sequencing to study genetic perturbations in mouse liver, identifying regulators of hepatocyte zonation and liver unfolded protein response.

bioRxiv · Nov 18, 2024 · PreprintGenomics

Ascertaining cells' synaptic connections and RNA expression simultaneously with massively barcoded rabies virus libraries

Arpiar B. Saunders, Kee Wui Huang, Cassandra J. Vondrak, Christina Hughes, Karina Smolyar, Harsha Sen, Adrienne C. Philson, James C. Nemesh, Alec Wysoker, Seva Kashin, Bernardo Luis Sabatini, Steven A. McCarroll

The paper introduces SBARRO, a method that maps synaptic connections and RNA expression in neurons using barcoded rabies virus and single-cell RNA sequencing, revealing cell-type-specific synaptic networks in mouse brain cells.

Nature Communications · Nov 16, 2022Peer-reviewedNeuroscience