Simultaneous mapping of RNA secondary, tertiary, and quaternary structure in living cells by multi-site DMS probing
Irfana Saleem, Thomas Miller, Lucas Kearns, Anthony Hoang, Joshua Meehan, Ritwika Bose, David B. Mitchell, David H. Price, Calla M. Olson, Chase A. Weidmann, Anthony M. Mustoe
The paper introduces msDMS-MaP, a method to map RNA secondary, tertiary, and quaternary structures in living cells using multi-site DMS probing, revealing structural motifs and protein binding sites.
Molecular Cell · Apr 21, 2026Peer-reviewedBiochemistry