Chase A. Weidmann

Robust mammalian RNA localization elements are complex and multipartite

The paper identifies that mammalian RNA localization elements are large, complex, and multipartite, requiring specific subsequences for function.

Simultaneous mapping of RNA secondary, tertiary, and quaternary structure in living cells by multi-site DMS probing

The paper introduces msDMS-MaP, a method to map RNA secondary, tertiary, and quaternary structures in living cells using multi-site DMS probing, revealing structural motifs and protein binding sites.

SHAPE-based chemical probes for studying preQ1-RNA interactions in living bacteria

This paper develops a chemical probing strategy using preQ1 and its riboswitch RNA to study RNA-small molecule interactions in living bacteria, mapping binding sites through mutational profiling.

Cytoplasmic localization of PUS7 facilitates a pseudouridine-dependent enhancement of cellular stress tolerance

This study shows that PUS7's cytoplasmic localization enhances stress tolerance by increasing pseudouridylation of mRNAs involved in metal and ROS homeostasis.

A 36-base hairpin within lncRNA DRAIC, which is modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes

The paper identifies a 36-base hairpin in lncRNA DRAIC that interacts with IKKα's coiled-coil domain, inhibits NF-κB activity, and suppresses tumor phenotypes through alternative splicing regulation.

Functional Validation of SAM Riboswitch Element A from Listeria monocytogenes

The paper validates SreA as a functional SAM-I riboswitch in Listeria monocytogenes through ligand binding, structure, and transcription assays, showing it binds SAM at lower concentrations than other SAM riboswitches but does not terminate transcription.

Structural conservation of MALAT1 long non-coding RNA in cells and in evolution

The paper investigates structural conservation of MALAT1 lncRNA across species and cell types using SHAPE chemical probing, finding uniform structural conservation despite sequence differences.

Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors

The paper identifies distinct structural domains in the MUNC lncRNA that regulate different promyogenic genes through cis and trans mechanisms.