Anthony M. Mustoe

The paper characterizes RNA G-quadruplex stability and recognition by ligands and proteins using a synthetic library and reverse-transcriptase stop sequencing.

The paper identifies non-coding G-quadruplex variants associated with plasma proteins and clinical traits, showing stronger signals when considering G4 stability impacts and integrating with protein-truncating variants.

This study introduces RAID-MaP to measure RNA structure within biomolecular condensates, revealing insights into rRNA folding and structural dynamics in the nucleolus and 7SK RNA.

The paper introduces msDMS-MaP, a method to map RNA secondary, tertiary, and quaternary structures in living cells using multi-site DMS probing, revealing structural motifs and protein binding sites.

This study introduces PRIME, a method to measure RNA structural energetics, finding that RNA base pairs and tertiary interactions dynamically open with low-energy fluctuations.

The paper identifies U-rich elements in 3' UTRs as drivers of cryptic splicing in MPRA, showing they affect splice site choice and expression levels.

The paper predicts variant effects on alternative splicing using structural probing data and a computational framework, achieving 90% accuracy for splice-altering variants.

The paper shows natural selection optimizes codon usage in the human genome, with dosage-sensitive and cell cycle genes being more intolerant to synonymous variation.