Resistance to antibacterial peptide nucleic acids through altered ribosome function
Jakob Frimodt-Møller, Irene Martinez-Roman, Thomas Prossliner, Lotta Happonen, Karen Leth Nielsen, Susanne Häußler, Elio Rossi, M. O'Connor, Peter Eigil Nielsen, Anders Løbner‐Olesen
This study identifies a ribosome-centered mechanism of resistance to antibacterial PNAs in E. coli, showing that mutations in ribosomal protein uS12 alter 30S assembly and translation-initiation dynamics, reducing PNA efficacy.
bioRxiv · Sep 9, 2026 · PreprintMolecular Biology