Elio Rossi

This study identifies a ribosome-centered mechanism of resistance to antibacterial PNAs in E. coli, showing that mutations in ribosomal protein uS12 alter 30S assembly and translation-initiation dynamics, reducing PNA efficacy.

This paper shows that 5-fluorocytosine inhibits biofilm formation and virulence in uropathogenic E. coli and synergizes with β-lactams to eradicate biofilm-embedded bacteria.